effects of oral zinc sulfate on hyperbilirubinemia in low-birth-weight neonates

نویسندگان

ashraf mohammadzadeh neonatal research center, imam reza hospital, faculty of medicine, mashhad university of medical sciences, mashhad, iran

ahmadshah farhat neonatal research center, imam reza hospital, faculty of medicine, mashhad university of medical sciences, mashhad, iran

ahmad ghasemian health science research center, faculty of medicine, mashhad university of medical sciences, mashhad, iran

mohammad ramezani pharmaceutical and biotechnology research center, faculty of pharmacy, mashhad university of medical sciences, mashhad, iran

چکیده

background: hyperbilirubinemia is one of the most common and persistent problems encountered in preterm newborns. this condition in preterm infant is more likely to be associated with neurological damage rather than terms. so far, no major studies have precisely assessed the effects of zinc sulfate on hyperbilirubinemia in low-birth-weight (lbw) neonates. therefore, in this study, we aimed to evaluate these effects in lbw infants. methods: this randomized, double-blind, clinical trial (irct201401041162n22) was performed on 61 icteric lbw neonates, hospitalized in the neonatal intensive care unit (nicu) of imam reza hospital in mashhad, iran from may 24, 2014 to may 24, 2015. the neonates were randomly divided into case and control groups, and the total serum bilirubin (tsb) level was measured at 0, 24, 48, 72, 96, and 120 h after treatment. the subjects received either 10 mg of zinc sulfate or placebo twice per day for five days (or by the end of treatment). the termination point of phototherapy was defined as a bilirubin level below 50% of the starting point. the collected data were analyzed, using spss version 20. chi-square, t-test, and repeated measures anova were carried out to compare the findings between the two groups. results: the mean tsb level was 14.87±2.65 and 14.73±3.22 mg/dl in the control and case groups. the mean decline in tsb level was only significant at 24 h after the treatment (2.71 and 2.13 mg/dl in the case and control groups, respectively; p=0.04), while being statistically insignificant on other days of the assessment. also, similar findings were reported regarding the duration of treatment in the case and control groups (58.84±14.97 and 65.60±16.59 h in the case and control groups, respectively). conclusion: the present study showed that administration of oral zinc sulfate in icteric lbw infants could significantly reduce tsb level only at 24 h following the treatment.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effects of oral zinc sulfate on hyperbilirubinemia in low-birth-weight neonates

Background: Hyperbilirubinemia is one of the most common and persistent problems encountered in preterm newborns. This condition in preterm infant is more likely to be associated with neurological damage rather than terms. So far, no major studies have precisely assessed the effects of zinc sulfate on hyperbilirubinemia in low-birth-weight (LBW) neonates. Therefore, in this study, we aimed to e...

متن کامل

Prophylactic effect of zinc sulphate on hyperbilirubinemia in premature very low birth weight neonates: a randomized clinical trial

Introduction: One of the common problems in neonatal period is jaundice that occurs in the first week of birth in 60% of term and 80% of preterm neonates. In preterm newborn hyperbilirubinaemia is higher, persistent, longer, and more likely to be associated with neurological injury than term neonates. The purpose of this study was to determine Prophylactic effect of zinc sulphate on hyperbiliru...

متن کامل

Clinical Effects of Carnitin Supplementation on Hypoglycemia, Apnea and Sepsis in Very Low Birth Weight Neonates

Background Systemic carnitine deficiency may present with apnea, hypotonia, and poor growth. Premature infants often manifest these symptoms and are at risk of developing carnitine deficiency because of immaturity of the biosynthetic pathway, lack of sufficient predelivery transplacental transport, and lack of sufficient exogenous supplementation. Objective This study was undertaken to examine ...

متن کامل

Effects of position on oxygen saturation and heart rate in very low birth weight neonates

Background: Desirable oxygenation of preterm newborns has particular importance, for this reason different methods have been proposed to improve oxygenation of the newborns; one of these methods is the newborns' position. The aim of this study was to determine the effect of the position of low birth weight neonates on arterial oxygen saturation and heart rate. Methods: This interventional st...

متن کامل

prophylactic effect of zinc sulphate on hyperbilirubinemia in premature very low birth weight neonates: a randomized clinical trial

introduction: one of the common problems in neonatal period is jaundice that occurs in the first week of birth in 60% of term and 80% of preterm neonates. in preterm newborn hyperbilirubinaemia is higher, persistent, longer, and more likely to be associated with neurological injury than term neonates. the purpose of this study was to determine prophylactic effect of zinc sulphate on hyperbiliru...

متن کامل

Prophylactic oral probiotic on prevention of feeding intolerance in Very Low Birth Weight (VLBW) neonates: Randomized Clinical Trial

Background: Feeding intolerance is prevalent in very low birth weight (VLBW) neonates and is a barrier for better and faster growth in these neonates. Some studies have supported the administration of oral probiotic to decrease feeding intolerance. The aim of this study was to evaluate the effect of probiotic on feeding intolerance in VLBW neonates. Methods: This randomized clinical trial st...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of neonatology

جلد ۷، شماره ۲، صفحات ۱۱-۱۵

کلمات کلیدی
[ ' h y p e r b i l i r u b i n e m i a ' , ' l b w ' , ' n e o n a t e ' , ' z i n c s u l f a t e 1 . s t o l l b j ' , ' k l i e g m a n r m . j a u n d i c e a n d h y p e r b i l i r u b i n e m i a i n t h e n e w b o r n . i n ' , ' k l i e g m a n r m ' , ' s t a n t o n b ' , ' g e m e j s ' , ' s c h o r n f ' , ' b e h r m a n r e ' , ' e d i t o r s . n e l s o n t e x t b o o k o f p e d i a t r i c s . 1 7 t h e d . p h i l a d e l p h i a ' , ' w b s a u n d e r s ' , ' 1 . s t o l l b j ' , ' k l i e g m a n r m . j a u n d i c e a n d h y p e r b i l i r u b i n e m i a i n t h e n e w b o r n . i n ' , ' k l i e g m a n r m ' , ' s t a n t o n b ' , ' g e m e j s ' , ' s c h o r n f ' , ' b e h r m a n r e ' , ' e d i t o r s . n e l s o n t e x t b o o k o f p e d i a t r i c s . 1 7 t h e d . p h i l a d e l p h i a ' , ' w b s a u n d e r s ' , ' 2 0 0 4 . p . 5 6 2 ' , 9 6 , ' 2 . b o s k a b a d i h ' , ' m a a m o u r i g ' , ' m a f i n e j a d s . t h e e f f e c t o f t r a d i t i o n a l r e m e d i e s ( c a m e l & a p o s ; ' , ' s t h o r n ' , ' f l i x w e e d a n d s u g a r w a t e r ) o n i d i o p a t h i c n e o n a t a l j a u n d i c e . i r a n j p e d i a t r . 2 0 1 1 ' , ' 2 1 ( 3 ) ' , 3 2 5 , 3 0 , ' 3 . b o s k a b a d i h ' , ' m a a m o u r i g ' , ' m a f i n e j a d s ' , ' r e z a g h o l i z a d e h f . c l i n i c a l c o u r s e a n d p r o g n o s i s o f h e m o l y t i c j a u n d i c e i n n e o n a t e s i n n o r t h e a s t o f i r a n . m a c e d j m e d s c i . 2 0 1 1 ' , ' 4 ( 4 ) ' , 4 0 3 , 7 , ' 4 . m a i s e l s m j ' , ' p a t h a k a ' , ' n e l s o n n m ' , ' n a t h a n d g ' , ' s m i t h c a . e n d o g e n o u s p r o d u c t i o n o f c a r b o n m o n o x i d e i n n o r m a l a n d e r y t h r o b l a s t o t i c n e w b o r n i n f a n t s . j c l i n i n v e s t . 1 9 7 1 ' , ' 5 0 ( 1 ) ' , 1 , 8 , ' 5 . a m b a l a v a r n a n ' , ' c a r l o w a . j a u n d i c e a n d h y p e r b i l i r u b i n e m i a . i n ' , ' k l i e g m a n r m ' , ' s t a n t o n b ' , ' g e m e j s ' , ' s c h o r n f ' , ' b e h r m a n r e ' , ' e d i t o r s . n e l s o n t e x t b o o k o f p e d i a t r i c s . 1 9 t h e d . p h i l a d e l p h i a ' , ' w b s a u n d e r s ' , ' 2 0 1 1 . p . 6 0 3 ' , 1 2 , ' 6 . k a p l a n m ' , ' w o n g r j ' , ' s i b l e y e ' , ' s t e v e n s o n d k . n e o n a t a l j a u n d i c e a n d l i v e r d i s e a s e . i n ' , ' m a r t i n r j ' , ' f a n a r o f f a a ' , ' w a l s h m c ' , ' e d i t o r s . f a n a r o f f a n d m a r t i n & a p o s ; ' , ' s n e o n a t a l ' , ' p e r i n a t a l m e d i c i n e . 9 t h e d . a m s t e r d a m ' , ' e l s e v i e r / m o s b y ' , ' 2 0 1 1 . p . 1 4 4 3 ' , 9 6 , ' 7 . j a h n s o n l h ' , ' b r o w n a k ' , ' b h u t a n i v k . s y s t e m ' , ' b a s e d a p p r o a c h t o m a n a g e m e n t o f n e o n a t a l j a u n d i c e a n d p r e v e n t i o n o f k e r n i c t e r u s . j p e d i a t r . 2 0 0 2 ' , ' 1 4 0 ( 4 ) ' , 3 9 6 , 4 0 3 , ' 8 . m a i s e l s m j . j a u n d i c e . i n ' , ' m a c d o n a l d m g ' , ' s e s h i a m m ' , ' m u l l e t t m d ' , ' e d i t o r s . a v e r y s n e o n a t o l o g y ' , ' p a t h o p h y s i o l o g y a n d m a n a g e m e n t o f t h e n e w b o r n . 6 t h e d . p h i l a d e l p h i a ' , ' l i p p i n c o t t w i l l i a m s & ' , ' w i l k i n s ' , ' 2 0 0 5 . p . 7 6 8 ' , 8 4 6 , ' 9 . k a w a d e n ' , ' o n i s h i s . t h e p r e n a t a l a n d p o s t n a t a l d e v e l o p m e n t o f u d p ' , ' g l u c u r o n y l t r a n s f e r a s e a c t i v i t y t o w a r d b i l i r u b i n a n d t h e e f f e c t o f p r e m a t u r e b i r t h o n t h i s a c t i v i t y i n t h e h u m a n l i v e r . b i o c h e m j . 1 9 8 1 ' , ' 1 9 6 ( 1 ) ' , 2 5 7 , 6 0 , ' 1 0 . m a r t i n r j ' , ' f a n a r o f f a a ' , ' w a l s h m c . f a n a r o f f a n d m a r t i n & a p o s ; ' , ' s n e o n a t a l ' , ' p e r i n a t a l m e d i c i n e ' , ' d i s e a s e s o f t h e f e t u s a n d i n f a n t . n e w y o r k ' , ' e l s e v i e r h e a l t h s c i e n c e s . 1 0 t h e d . 2 0 1 5 ' , ' p . 1 6 2 1 ' , 2 3 , ' 1 1 . m é n d e z ' , ' s á n c h e z n ' , ' r o l d á n ' , ' v a l a d e z e ' , ' f l o r e s m a ' , ' c á r d e n a s ' , ' v á z q u e z r ' , ' u r i b e m . z i n c s a l t s p r e c i p i t a t e u n c o n j u g a t e d b i l i r u b i n i n v i t r o a n d i n h i b i t e n t e r o h e p a t i c c y c l i n g o f b i l i r u b i n i n h a m s t e r s . e u r j c l i n i n v e s t . 2 0 0 1 ' , ' 3 1 ( 9 ) ' , 7 7 3 , 8 0 , ' 1 2 . m e n d e z ' , ' s a n c h e z n ' , ' m a r t i n e z m ' , ' g o n z a l e z v ' , ' r o l d a n ' , ' v a l a d e z e ' , ' f l o r e s m a ' , ' u r i b e m . z i n c s u l f a t e i n h i b i t s t h e e n t e r o h e p a t i c c y c l i n g o f u n c o n j u g a t e d b i l i r u b i n i n s u b j e c t s w i t h g i l b e r t & a p o s ; ' , ' s s y n d r o m e . a n n h e p a t o l . 2 0 0 2 ' , ' 1 ( 1 ) ' , 4 0 , 3 , ' 1 3 . m a i s e l s m j ' , ' o s t r e a e m j r ' , ' t o u c h s ' , ' c l u n e s e ' , ' c e p e d a e ' , ' k r i n g e ' , ' e t a l . e v a l u a t i o n o f a n e w t r a n s c u t a n e o u s b i l i r u b i n o m e t e r . p e d i a t r i c . 2 0 0 4 ' , ' 1 1 3 ( 6 ) ' , 1 6 2 8 , 3 5 , ' 1 4 . l a t h e g h ' , ' r u t h v e n c r . f a c t o r s a f f e c t i n g t h e r a t e o f c o u p l i n g o f b i l i r u b i n a n d c o n j u g a t e d b i l i r u b i n i n t h e v a n d e b e r g h r e a c t i o n . j c l i n p a t h o l . 1 9 5 8 ' , ' 1 1 ( 2 ) ' , 1 5 5 , 6 1 , ' 1 5 . m a r t i n r j ' , ' f a n a r o f f a a ' , ' w a l s h m c . f a n a r o f f a n d m a r t i n & a p o s ; ' , ' s n e o n a t a l ' , ' p e r i n a t a l m e d i c i n e ' , ' d i s e a s e s o f t h e f e t u s a n d i n f a n t . 9 t h e d . n e w y o r k ' , ' e l s e v i e r h e a l t h s c i e n c e s ' , ' 2 0 1 1 . p . 1 4 7 6 ' , ' 1 6 . m o h a m m a d z a d e a ' , ' f a r h a t a s ' , ' a m i r i r ' , ' e s m a e l y h ' , ' b a g h e r i s . t r e a t m e n t e f f e c t o f c l o f i b r a t e i n j a u n d i c e d l o w b i r t h w e i g h t n e o n a t e s . i n t j h e m a t o l o n c o l . 2 0 0 9 ' , ' 1 9 ( 2 ) ' , 1 0 0 , 5 , ' 1 7 . r a n a n ' , ' m i s h r a s ' , ' b h a t n a g a r s ' , ' p a u l v ' , ' d e o r a r i a k ' , ' a g a r w a l r . e f f i c a c y o f z i n c i n r e d u c i n g h y p e r b i l i r u b i n e m i a a m o n g a t ' , ' r i s k n e o n a t e s ' , ' a r a n d o m i z e d ' , ' d o u b l e ' , ' b l i n d ' , ' p l a c e b o ' , ' c o n t r o l l e d t r i a l . i n d i a n j p e d i a t r . 2 0 1 1 ' , ' 7 8 ( 9 ) ' , 1 0 7 3 , 8 , ' 1 8 . m o h a m m a d z a d e h a ' , ' k h o r a k i a n f ' , ' r a m e z a n i m . p r o p h y l a c t i c e f f e c t o f z i n c s u l f a t e o n h y p e r b i l i r u b i n e m i a i n p r e m a t u r e v e r y l o w b i r t h w e i g h t n e o n a t e s ' , ' a r a n d o m i z e d c l i n i c a l t r i a l . i r a n j n e o n a t o l . 2 0 1 5 ' , ' 5 ( 4 ) ' , 6 , 1 0 , ' 1 9 . m a a m o u r i g ' , ' b o s k a b a d i h ' , ' m a f i n e j a d s ' , ' b o z o r g n i a y ' , ' k h a k s h u r a . e f f i c a c y o f o r a l z i n c s u l f a t e i n t a k e i n p r e v e n t i o n o f n e o n a t a l j a u n d i c e . i r a n j n e o n a t o l . 2 0 1 3 ' , ' 4 ( 4 ) ' , 1 1 , 6 , ' 2 0 . p a t t o n d r ' , ' s u k a d i a . e f f e c t o f o r a l z i n c o n h y p e r b i l i r u b i n e m i a i n f u l l t e r m n e o n a t e s . p a e d i a t r i n d o n e s . 2 0 1 1 ' , ' 5 1 ( 2 ) ' , 1 0 7 , 1 0 , ' 2 1 . s t r a n d t a ' , ' c h a n d y o r k ' , ' b a h l r ' , ' s h a r m a p r ' , ' a d h i k a r i r k ' , ' b h a n d a r i n ' , ' e t a l . e f f e c t i v e n e s s a n d e f f i c a c y o f z i n c f o r t h e t r e a t m e n t o f a c u t e d i a r r h e a i n y o u n g c h i l d r e n . p e d i a t r i c s . 2 0 0 2 ' , ' 1 0 9 ( 5 ) ' , ' 8 9 8 9 0 3 ' , ' 2 2 . b a h l r ' , ' b h a n d a r i n ' , ' s a k s e n a m ' , ' s t r a n d t ' , ' k u m a r g t ' , ' b h a n m k ' , ' e t a l . e f f i c a c y o f z i n c f o r t i f i e d o r a l r e h y d r a t i o n s o l u t i o n i n 6 ' , ' t o 3 5 ' , ' m o n t h ' , ' o l d c h i l d r e n w i t h a c u t e d i a r r h e a . j p e d i a t r . 2 0 0 2 ' , ' 1 4 1 ( 5 ) ' , ' 6 7 7 8 2 ' , ' 2 3 . f i s c h e r c ' , ' h a r v e y p . l o w r i s k s o f a d v e r s e e f f e c t s f r o m z i n c s u p p l e m e n t a t i o n . a r l i n g t o n ' , ' t h e u s a i d m i c r o n u t r i e n t p r o g r a m ' , 2 0 0 5 ]

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023